Copper-promoted Chan-Lam coupling between enaminones and aryl boronic acids
2018
Abstract A novel copper-promoted N- arylation of enaminones with aromatic boronic acids has been developed, which provides an efficient way to synthesize N -aryl enaminones with a broad substrate scope and excellent functional group compatibility. The N -aryl enaminones could be converted into a series of highly valuable building blocks and bioactive compounds. Notably, in comparison with traditional methods, this alternative approach provides accesses to N -aryl enaminones bearing multiple aromatic rings.
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