Carbon Nanoparticles-Fe(II) Complex for Efficient Tumor Inhibition with Low Toxicity by Amplifying Oxidative Stress.
2020
The Fe element is
essential for human beings, but overdose of Fe leads to unwanted toxicity.
However, overwhelming Fe accumulation in tumor cells could arouse
strong oxidative stress for cancer therapy. Therefore, the fast and
specific accumulation of Fe in tumor cells without systemic toxicity
is critical for this purpose. Herein, we report that a carbon nanoparticles–Fe(II)
complex (CNSI–Fe) could efficiently load Fe into tumor cells
and inhibit tumor growth with low toxicity in H22 tumor-bearing mice.
Upon intratumoral injection, CNSI–Fe only induced meaningful
Fe increase in the tumor to significantly inhibit tumor growth with
competitive efficiency to cis-dichlorodiammineplatinum(II).
Fe accumulation stimulated the hydroxyl radical generation and serious
oxidative stress in the tumor. Due to the lack of Fe accumulation
in other tissues, CNSI–Fe was of low systemic toxicity to tumor-bearing
mice. With the clinical success of CNSI for decades, CNSI–Fe
might be used for cancer therapy through “off label”
use to benefit patients immediately.
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