An Mb1-Cre-driven oncogenic Kras mutation results in a mouse model of T-acute lymphoblastic leukemia/lymphoma with short latency and high penetrance.

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CAS Article Google Scholar Download references This work was supported by an American Society of Hematology Scholar Award (JJJ); grant RP170074 from the Cancer Prevention and Research Institute of Texas (KRR); funding from the Lynch family (KRR); and by the National Cancer Institute, National Institutes of Health (R01 CA207086 to HDL). Flow cytometry assays were performed at the Research Flow Cytometry Core Facility of Texas Children’s Cancer and Hematology Centers with the support from the Cytometry and Cell Sorting Core at Baylor College of Medicine with funding from the CPRIT Core Facility Support Award (CPRIT-RP180672), the NIH (CA125123 and RR024574), and the assistance of Joel M. Sederstrom. Flow assistance was also generously provided by Amos Gaikwad and Tatiana Goltsova. Histology was performed by the BCM Center for Comparative Medicine Comparative Pathology Laboratory with the assistance of Brian Simons. Microscope assistance was generously provided by Debananda Pati and Nenggang Zhang. Texas Children’s Cancer Center, Department of Pediatrics, Baylor College of Medicine (BCM), Houston, TX, USA Jacob J. Junco, Raushan Rashid, Maci Terrell, Vincent U. Gant Jr., Matthew Miller, Rachel Rau & Karen R. Rabin Department of Pathology & Immunology, BCM, Houston, TX, USA Taylor Chen & H. Daniel Lacorazza Stem Cells and Regenerative Medicine Center, Departments of Pediatrics and of Molecular & Human Genetics, BCM, Houston, TX, USA Matthew Miller & Rachel Rau You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar Correspondence to Jacob J. Junco. The authors declare that they have no conflict of interest. Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Reprints and Permissions Junco, J.J., Chen, T., Rashid, R. et al. An Mb1-Cre-driven...