Polymorphic investigation and interpopulation genetic differentiation analyses of 20 STR loci in Inner Mongolia Han population

Abstract Introduction Investigating the forensic genetic features and providing basic population data of Han population are of great significance. Materials & methods Hence, we focused on the Han population in Inner Mongolia Autonomous Region of China, and simultaneously calculated the allelic frequencies as well as forensic statistical parameters of the 20 autosomal STRs based on the genotype results from 455 unrelated individuals. Results Statistical analysis results indicated that no significant departures were observed from Hardy-Weinberg equilibrium tests at 20 STRs except locus D19S433. The range of allelic frequencies in the studied loci was from 0.0011 to 0.5187. The locus Penta E with most allelic numbers was observed as the most polymorphic locus with the highest values of discrimination power and polymorphic information content. Subsequently, the combined power of discrimination and combined probability of exclusion were calculated to be 0.99999999999999999999999 and 0.999999996 in Inner Mongolia Han population, respectively. In addition, interpopulation genetic affinities between the Han population and 12 reference groups were performed via different statistical analyses. Conclusion Phylogenetic analysis, principal component analysis as well as population structure analysis indicated that the studied Han population shared intimate genetic relationships to Yunnan Han population.