Evaluating the Specificity and Potency of Activators and Inhibitors of the cAMP Sensors PKA, Epac2/Rapgef4, and NCS/Rapgef2 Using Cell-Based Assays for Activation of CREB, p38 MAPK, and ERK

Cyclic AMP elevation is well known to cause dividing neuroendocrine (e.g. PC12) cells to differentiate through a process that includes growth arrest, neurite extension, and induction of neuronal ge...