Protein kinase C is a calcium sensor for presynaptic short-term plasticity

2014 
In presynaptic boutons, calcium (Ca 2+ ) triggers both neurotransmitter release and short-term synaptic plasticity. Whereas synaptotagmins are known to mediate vesicle fusion through binding of high local Ca 2+ to their C2 domains, the proteins that sense smaller global Ca 2+ increases to produce short-term plasticity have remained elusive. Here, we identify a Ca 2+ sensor for post-
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