The Effects of Daily Repeated Magnetic Field on S-Nitroso-N- acetyl-DL penicillamine Induced Hyperalgesia Günlük olarak tekrarlanan manyetik alan uygulamasinin-Nitroso-N-acetyl-DL penicillamine tarafindan indüklenen hiperaljezi üzerine olan etkisi

Aim. The treatment of pain has been one of the most important objectives of medicine. We aimed to investigate antinociceptive effects and mechanisms of magnetic field (MF) on the hyperalgesia produced by S-Nitroso N-acetyl penicillamine (SNAP). Method. Study has been made in two sections. In the first section, rats were divided four groups (six in each). The first group was determined as sham group and administrated 0.3 mL, 0.9% NaCl intraperitoneally (i.p) before assessing tail flick latencies (TFLs) (Sham group). In the second group, 2 mg/kg SNAP administrated i.p. and TFLs were assessed at the same time points with first group (SNAP group). In the third group, rats were repeatedly exposed to MF for 6 consecutive days (MF group). In the fourth group, SNAP was administrated i.p everyday shortly before MF exposure (SNAP+MF group). In the second section, animals divided to the same groups with the first section. Same procedures have been performed with the first section groups and blood samples were collected to determine plasma levels of β-endorphin and substance P. Results. SNAP (2 mg/kg) produced hyperalgesic effect with i.p. administration. MF application (5 mT and 165 min per day) produced a strong antinociception in Days 3 and 4. Tail flick values of SNAP+MF in Days 3 and 4 were found to be significantly low as compared to MF and Sham groups. In SNAP group, substance P levels were found to be significantly high. Plasma β-endorphin levels in MF and SNAP+MF groups were significantly high as compared to the Sham group. Conclusion. MF may be an alternative antinociceptive approach for pain treatment. There is need for further studies to overcome the tolerance to antinociceptive effects of MF.