Analysis of Conformational and Sequential IgE Epitopes on the Major Allergen Cry j 2 of Japanese Cedar (Cryptomeria japonica) Pollen in Humans by Using Monoclonal Antibodies for Cry j 2

Purpose Japanese cedar (Cryptomeria japonica; CJ) pollinosis is a type I allergy induced by CJ pollen, and Cry j 2 is one of the major allergens in this pollen. In a previous study, we analyzed IgE epitopes on Cry j 2 in humans by using synthetic peptides. The main purpose of this study was to identify B-cell epitopes on Cry j 2 in patients with CJ pollinosis by using monoclonal antibodies (mAbs) for Cry j 2.