Binding mode of Pyridoclax to Myeloid cell leukemia-1 (Mcl-1) revealed by Nuclear Magnetic Resonance Spectroscopy, Docking and Molecular Dynamics Approaches

A. Bourafai-Aziez,M. Sebban,M. Benabderrahmane,Bogdan A. Marekha,Camille Denis,H. Paysant,Louis-Bastien Weiswald,Ludovic Carlier,Ronan Bureau,G. Coadou,D. Ravault,Anne-Sophie Voisin-Chiret,J. Sopková-de Oliveira Santos,H. Oulyadi

Binding mode of Pyridoclax to Myeloid cell leukemia-1 (Mcl-1) revealed by Nuclear Magnetic Resonance Spectroscopy, Docking and Molecular Dynamics Approaches

2019

A. Bourafai-Aziez
M. Sebban
M. Benabderrahmane
Bogdan A. Marekha
Camille Denis
H. Paysant
Louis-Bastien Weiswald
Ludovic Carlier
Ronan Bureau
G. Coadou
D. Ravault
Anne-Sophie Voisin-Chiret
J. Sopková-de Oliveira Santos
H. Oulyadi

Myeloid cell leukemia-1 (Mcl-1) is an anti-apoptotic member of the Bcl-2 family proteins. Its amplification is one of the most frequent genetic aberrations found in human cancers. Pyridoclax, a pro...

Keywords:

Nuclear magnetic resonance spectroscopy
Cell
Docking (dog)
Biochemistry
Chemistry
Leukemia
Molecular dynamics
Myeloid
gene deletion

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