The induction of broad CD4+ and CD8+ T cell responses and cross-neutralizing antibodies against the hepatitis C virus (HCV) by vaccinating with Th1-adjuvanted polypeptides followed by defective alphaviral particles expressing envelope glycoproteins gpE1/gpE2 and nonstructural proteins 3, 4 & 5 Running title: Induction of broad anti-HCV responses by an optimized regimen