CXCR7 participates in CXCL12-induced CD34+ cell cycling through β-arrestin–dependent Akt activation

In addition to its well-known effect on migration and homing of hematopoietic stem/progenitor cells (HSPCs), CXCL12 chemokine also exhibits a cell cycle and survival-promoting factor for human CD34+ HSPCs. CXCR4 was suggested to be responsible for CXCL12-induced biological effects until the recent