In situ generation of active species “NO” for the aerobic oxidative deprotection of aldoximes catalyzed by FeCl3/TEMPO

A simple and efficient aerobic oxidative deoximation system, using molecular oxygen as the green oxidant and FeCl3/TEMPO as the catalyst, is developed for a wide range of aldoximes. Notably, nitric oxide (NO), an active species for aerobic oxidation reactions, is assumed to be generated in situ from the cleavage of oximes and further confirmed by the existence of a large quantity of NO3− by Ionic Chromatography (IC).