Letter by Villa Abrille et al Regarding Article, “Hyperactive Adverse Mechanical Stress Responses in Dystrophic Heart Are Coupled to Transient Receptor Potential Canonical 6 and Blocked by cGMP-Protein Kinase G Modulation”

The recent article by Seo et al,1 published in Circulation Research , presented many interesting aspects of the myocardium from mice lacking transient receptor potential canonical channels TRPC3 or TRPC6, from dystrophic animals, and their interaction with cGMP. These authors measured the muscle response to stretch, widely known as slow force response (SFR). We would like to comment only on one aspect of …