The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size

Lara Planas-Paz,Vanessa Orsini,Luke Boulter,Diego Calabrese,Monika Pikiolek,Florian Nigsch,Yang Xie,Guglielmo Roma,Adriana Donovan,Patricia Marti,Nicolau Beckmann,Michael T. Dill,Walter Carbone,Sebastian Bergling,Andrea Isken,Matthias Mueller,Bernd Kinzel,Yi Yang,Xiaohong Mao,Thomas B. Nicholson,Raffaella Zamponi,Paola Capodieci,Reginald Valdez,Daniel Rivera,Andreas Loew,Chinweike Ukomadu,Luigi Terracciano,Tewis Bouwmeester,Feng Cong,Markus H. Heim,Stuart J. Forbes,Heinz Ruffner,Jan S. Tchorz

The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size

2016

Tchorz and colleagues identify a role for the RSPO–LGR4/5–ZNRF3/RNF43 module as master regulator of Wnt/β-catenin-mediated metabolic liver zonation and hepatic growth/size control during development, homeostasis and regeneration.

Keywords:

Liver regeneration
Cell biology
Homeostasis
Wnt signaling pathway
Cell lineage
Cytochrome P-450 CYP2E1
Regulator
Biology
gene deletion
master regulator

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