Aspherical and Spherical InvA497-Functionalized Nanocarriers for Intracellular Delivery of Anti-Infective Agents

Arianna Castoldi,Martin Empting,Chiara De Rossi,Karsten Mayr,Petra Dersch,Rolf W. Hartmann,Rolf Müller,Sarah Gordon,Claus-Michael Lehr

Aspherical and Spherical InvA497-Functionalized Nanocarriers for Intracellular Delivery of Anti-Infective Agents

2019

Arianna Castoldi
Martin Empting
Chiara De Rossi
Karsten Mayr
Petra Dersch
Rolf W. Hartmann
Rolf Müller
Sarah Gordon
Claus-Michael Lehr

Purpose The objective of this work was to evaluate the potential of polymeric spherical and aspherical invasive nanocarriers, loaded with antibiotic, to access and treat intracellular bacterial infections.

Keywords:

Nanocarriers
Intracellular
Biochemistry
Antibiotics
Anti-Infective Agents
Chemistry
dose dependence
Biophysics
Gentamicin
Intracellular parasite
Shigella flexneri
bacterial killing

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