The effect of testosterone on rat bone marrow nuclear ribonucleic acid metabolism

Abstract The effect of testosterone on the metabolism of nuclear RNA (nRNA) of female rat bone marrow was studied. The hormone increased the incorporation of 14 C-formate into total nRNA. The sedimentation analysis of nRNA showed that testosterone stimulates preferentially the incorporation of the labelled precursor into species with sedimentation coefficients higher than 30 S. A concomitant effect of the hormone on the stimulation of nuclear ribonuclease activity was also observed. The probable significance of these facts is discussed.