OXA-PROSTANOID ANALOGS. IDENTIFICATION OF AN ORALLY EFFECTIVE, DUAL THROMBOXANE RECEPTOR ANTAGONIST/THROMBOXANE SYNTHASE INHIBITOR

Isidoros Vlattas,James Dellureficio,David S. Cohen,Wai Lee,F. Clarke,Ronald Dotson,J. Mathis,H. Zoganas

OXA-PROSTANOID ANALOGS. IDENTIFICATION OF AN ORALLY EFFECTIVE, DUAL THROMBOXANE RECEPTOR ANTAGONIST/THROMBOXANE SYNTHASE INHIBITOR

1994

Isidoros Vlattas
James Dellureficio
David S. Cohen
Wai Lee
F. Clarke
Ronald Dotson
J. Mathis
H. Zoganas

The synthesis and pharmacological evaluation of oxa-prostanoid analogs with dual thromboxane receptor antagonist (TxRA)/thromboxane synthase inhibitor (TxSI) activities are described. One analog 6 with the desirable long lasting oral TxRA/TxSI activity has been identified.

Keywords:

Prostanoid
Biochemistry
Thromboxane receptor
Thromboxane-A synthase
Chemistry
thromboxane receptor antagonist
long lasting

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