The Development of a Manufacturing Route to an MCHr1 Antagonist

Michael David Golden,Danny Legg,David Milne,M Arun Bharadwaj,K. Deepthi,Madan Gopal,Nagaraju Dokka,Sudhir Nambiar,Puranik Ramachandra,U. Santhosh,Parhalad Sharma,R. Sridharan,Manjunatha Sulur,Mats Linderberg,Anders Nilsson,Roger Sohlberg,John Kremers,Samuel Oliver,Debasis Patra

The Development of a Manufacturing Route to an MCHr1 Antagonist

2016

Michael David Golden
Danny Legg
David Milne
M Arun Bharadwaj
K. Deepthi
Madan Gopal
Nagaraju Dokka
Sudhir Nambiar
Puranik Ramachandra
U. Santhosh
Parhalad Sharma
R. Sridharan
Manjunatha Sulur
Mats Linderberg
Anders Nilsson
Roger Sohlberg
John Kremers
Samuel Oliver
Debasis Patra

Process development work to provide an efficient manufacturing route to a MCHr1 antagonist is presented herewith. Features of this development work include a scalable manufacturing route to the useful 6-oxa-2-azaspiro[3.3]heptane building block and the use of a (soluble) alternative to sodium triacetoxyborohydride.

Keywords:

Inorganic chemistry
Chemistry
Sodium triacetoxyborohydride
Heptane
Antagonist
Organic chemistry
process development

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