The Evaluation of Therapeutic Efficacy and Safety Profile of Simvastatin Prodrug Micelles in a Closed Fracture Mouse Model

Yijia Zhang,Zhenshan Jia,Hongjiang Yuan,Anand Dusad,Ke Ren,Xin Wei,Edward V. Fehringer,P. Edward Purdue,Aaron Daluiski,Steven R. Goldring,Dong Wang

The Evaluation of Therapeutic Efficacy and Safety Profile of Simvastatin Prodrug Micelles in a Closed Fracture Mouse Model

2016

Yijia Zhang
Zhenshan Jia
Hongjiang Yuan
Anand Dusad
Ke Ren
Xin Wei
Edward V. Fehringer
P. Edward Purdue
Aaron Daluiski
Steven R. Goldring
Dong Wang

Purpose To evaluate the therapeutic efficiency of a micellar prodrug formulation of simvastatin (SIM/SIM-mPEG) and explore its safety in a closed femoral fracture mouse model.

Keywords:

Pharmacology
Simvastatin
Femoral fracture
Closed Fracture
Chemistry
Prodrug
Micelle
safety profile
pharmacology toxicology
treatment outcome

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