Synthesis and activity of 2,6,9-trisubstituted purines

Steven R. Schow,Richard Mackman,Cheri Lynn Blum,Eric E. Brooks,Amy G. Horsma,Alison Joly,S.S. Kerwar,Gavin Lee,Dov Shiffman,Marek G. Nelson,Xingbo Wang,M. Michael Wick,Xiaoming Zhang,Robert T. Lum

Synthesis and activity of 2,6,9-trisubstituted purines

1997

Steven R. Schow
Richard Mackman
Cheri Lynn Blum
Eric E. Brooks
Amy G. Horsma
Alison Joly
S.S. Kerwar
Gavin Lee
Dov Shiffman
Marek G. Nelson
Xingbo Wang
M. Michael Wick
Xiaoming Zhang
Robert T. Lum

The preparation of a series of 2,6,9-trisubstituted purines and the structure-activity data for the inhibition of cyclin dependent kinase, CDK2 are presented.

Keywords:

Enzyme
Chemical synthesis
Protein kinase A
Cyclin-dependent kinase 2
Cyclin-dependent kinase
Enzyme inhibitor
Purine metabolism
Chemistry
Biochemistry
Stereochemistry
In vitro

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