Related substances of azilsartan medoxomil: Synthesis and characterization
2015
AzilsartanMedoxomil is the prodrug 2-ethoxy-1-([2'-(5- oxo 4, 5 – dihydro - 1, 2, 4-oxadiazol-3-yl) biphenyl-4- yl]methyl) 1H-benimidazole-7-carboxylic acid which is used as a antihypertensive drug. During the process optimization of Azilsartanmedoxomil novel related substances (impurities) were observed. These related substances were prepared and characterized by MASS, NMR and HPLC.
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