Expanding the limit of Pd-catalyzed decarboxylative benzylations
2018
The Pd-catalyzed decarboxylative cross-coupling of electron-deficient aryl acetates with aryl bromides is reported. The method widens the scope of benzylic partners that can undergo efficient reactivity from highly activated nitrophenylacetates established previously, to a diverse series of substrates bearing modestly stabilizing groups, allowing direct access to functionalized diarylmethanes. Mechanistic studies support the role of dienolates as key intermediates in the coupling process.
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