Combinatorial synthesis of 3-(amidoalkyl) and 3-(aminoalkyl)-2-arylindole derivatives: Discovery of potent ligands for a variety of G-protein coupled receptors

Christopher A. Willoughby,Steven M. Hutchins,Keith G. Rosauer,Madhumeeta J Dhar,Kevin T. Chapman,Gary G. Chicchi,Sharon Sadowski,David H. Weinberg,Smita Patel,Lorraine Malkowitz,Jerry Di Salvo,Stephen Pacholok,Kang Cheng

Combinatorial synthesis of 3-(amidoalkyl) and 3-(aminoalkyl)-2-arylindole derivatives: Discovery of potent ligands for a variety of G-protein coupled receptors

2002

Christopher A. Willoughby
Steven M. Hutchins
Keith G. Rosauer
Madhumeeta J Dhar
Kevin T. Chapman
Gary G. Chicchi
Sharon Sadowski
David H. Weinberg
Smita Patel
Lorraine Malkowitz
Jerry Di Salvo
Stephen Pacholok
Kang Cheng

Preparation and screening of mixture libraries based on a 2-arylindole scaffold resulted in the discovery of potent ligands for a variety of G-protein coupled receptors.

Keywords:

G protein
G protein-coupled receptor
Organic chemistry
Bicyclic molecule
Biochemistry
Chemistry
Ligand
Receptor
Carboxamide
Chemical synthesis
Amine gas treating
Stereochemistry

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