HUMAN T CELL PROLIFERATION IN RESPONSE TO THROMBIN-ACTIVATED GTKO PIG ENDOTHELIAL CELLS

Background Thrombin formation is a key feature in the activation of coagulation in pig xenograft recipients. As thrombin is known to activate endothelial and immune cells, we explored whether thrombin activation of pig endothelial cells (EC) was associated with an increased human T cell response.