Schwarzinicines A–G, 1,4-Diarylbutanoid–Phenethylamine Conjugates from the Leaves of Ficus schwarzii

2020 
Schwarzinicines A–G (1–7), representing the first examples of 1,4-diarylbutanoid–phenethylamine conjugates, were isolated from the leaves of Ficus schwarzii. The structures of these compounds were determined by detailed analysis of their MS, 1D and 2D NMR data. Compounds 1–4 exhibited pronounced vasorelaxant effects in the rat isolated aorta (Emax 106–120%; EC50 0.96–2.10 μM). However, compounds 1 and 2 showed no cytotoxic effects against A549, MCF-7, and HCT 116 human cancer cells (IC50 > 10 μM).
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