Plasticity of Mycoplasmas: Changes in the Genomic Profile, as well as in the Cellular and Vesicular Proteomes of the Acholeplasma laidlawii in Adapting the Bacterium to Different Environmental Conditions

For the first time as a result of the comparative analysis of proteomes of cells and extracellular vesicles, as well as the complete nucleotide sequence of Acholeplasma laidlawii cells under various conditions of growth of the mycoplasma, the evidence of a high level of plasticity of this bacterium, providing a rapid adaptation to stressors associated with the SOS response, was obtained. The battery of genes with targeted potential for the infekta control system using CRISPR tools was revealed.