Synthesis of 14C‐labeled N‐nitrosobis (2‐oxopropyl) amine
1981
N-Nitrosobis (2-oxopropyl) amine (BOP), a potent and selective pancreatic carcinogen in the Syrian golden hamster was synthesized with a 14C label in the alpha carbon. Oxidation of 2-hydroxypropyl-2-hydroxypropyl-1-14C-amine followed by nitrosation with sodium nitrite and hydrochloric acid gave radiolabeled BOP in 60% yield.
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