Enantioconvergent hydrolysis of racemic styrene oxide at high concentration by a pair of novel epoxide hydrolases into (R)-phenyl-1,2-ethanediol

Rui Wang,Die Hu,Xun-Cheng Zong,Jin-Ping Li,Lei Ding,Minchen Wu,Jianfang Li

Enantioconvergent hydrolysis of racemic styrene oxide at high concentration by a pair of novel epoxide hydrolases into (R)-phenyl-1,2-ethanediol

2017

Rui Wang
Die Hu
Xun-Cheng Zong
Jin-Ping Li
Lei Ding
Minchen Wu
Jianfang Li

Objectives To prepare (R)-phenyl-1,2-ethanediol ((R)-PED) with high enantiomeric excess (ee p) and yield from racemic styrene oxide (rac-SO) at high concentration by bi-enzymatic catalysis.

Keywords:

Epoxide Hydrolases
Styrene oxide
Epoxide hydrolase
Biochemistry
Hydrolysis
Catalysis
Enantiomeric excess
Stereochemistry
Chemistry
Organic chemistry
high concentration

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