Highly specific in vivo gene delivery for p53-mediated apoptosis and genetic photodynamic therapies of tumour
2015
Alterations of p53 are associated with more than half of all human cancers. Here the authors present a new pH-sensitive nanoparticle that is delivered via systemic circulation and combines gene delivery to restore p53 with expression of Killerred protein to induce photosensitization.
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