The change of mitochondrial respiratory chain complex in patients with myelodysplastic syndrome

Objective:To investigate the function of mitochondrial respiratory chain in bone marrow mononuclear cell(BMMNC)of myelodysplastic syndrome(MDS)and its relationship with MDS.Method:Activities of respiratory chain complexes Ⅰ,Ⅲ and Ⅳ were examined in BMMNC from 26 patients with MDS and 10 normal controls.Result:Activities of respiratory chain complexes Ⅰ,Ⅲ and Ⅳ in BMMNC were significantly lower in MDS patients than that in normal controls(P0.05).According to WHO classification,activities of respiratory chain complexes Ⅰ、Ⅲ and Ⅳ in BMMNC were significantly lower in MDS RAEB-Ⅰ,RAEB-Ⅱ and RA,RARS than normal controls(P0.05).Activities of respiratory chain complexes Ⅰ and Ⅲ in type RAEB-Ⅰ,RAEB-Ⅱ and type RA、RARS showed no significance difference(P0.05),but the activities,of respiratory chain complexes Ⅳ was significantly higher in MDS RAEB-Ⅰ,RAEB-Ⅱ than RA,RARS(P0.05).Conclusion:Reduced activities of respiratory chain complexes may be related to dysplastic hematopoiesis and ineffective hematopoiesis.