Relationship between rs7903146-T/C polymorphism of TCF7L2 gene and gestational diabetes mellitus

Objective To investigate the relationship between rs7903146-T/C polymorphism of transcription factor7-like 2 gene (TCF7L2) gene and gestational diabetes mellitus in Han population of Liaoning province. Methods The rs7903146-T/C polymorphism was detected in 115 healthy Han controls and 113 patients with gestational diabetes mellitus by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results There were three genotypes: CC, CT, and TT; and their frequencies in control group and patients were 95.65%/84.96%, 4.35%/15.04%, and 0/0, respectively. The allele frequency T of rs7903146 in control group and the patients was 2.17% and 7.52%, respectively. There was statistical difference between two groups. Conclusions The rs7903146-T/C polymorphism of TCF7L2 might be associated with gestational diabetes mellitus in Liaoning Han population. Key words: Transcription factors; Polymorphism, genetic; Diabetes, gestational; Polymerase chain reaction