Cytotoxic activity of some novel sulfonamide derivatives.

The versatile synthons 2-chloro-N-(4-sulfamoylphenyl)acetamides 1a,b were used as a key interme- diates for the synthesis of sulfonamide derivatives with adamantyl 2, indene 3, morpholinophenyl 4, pipronyl 5, benzothiazole 6n8, pyrazole 9, thiadiazole 10, 11, quinoline 12, isoquinoline 13, thiazoles 14n19, acrylamides 20n24 and benzochromene 25 moieties via reaction with several nitrogen nucleophiles. The newly synthesized compounds were screened in vitro for their anticancer activity against breast cancer (MDA-MB-231) and colon cancer (HT-29) cell lines. Compound 17 was found to be the most potent against breast cancer cell lines with IC50 value 66.6 µM compared with the reference drug 5-fluorouracil with IC50 value 77.28 µM.