Prolonged activation of human islet cannabinoid receptors in vitro induces adaptation but not dysfunction.
2016
Background
Although in vivo studies have implicated endocannabinoids in metabolic dysfunction, little is known about direct, chronic activation of the endocannabinoid system (ECS) in human islets. Therefore, this study investigated the effects of prolonged exposure to cannabinoid agonists on human islet gene expression and function.
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