Synthesis and Acaricidal Activity of Aryl-Spirobutyrolactone Derivatives against Spider Mites under Greenhouse and Field Conditions

Propesticides play an important role in modern agrochemicals research and development. In the controlling of harmful insects and mites in agriculture, propesticide strategy offers a unique and modern approach to acaricide development. In this study, a series of aryl-spirobutyrolactone pharmacophore based alkylated compounds were synthesized and characterized by 1H NMR and ESI-MS. All of this compounds exhibited excellent acaricidal activities against Tetranychus cinnabarinus at 2.5 mg/L in greenhouse test, and some of them showed better activity than spirodiclofen against eggs of T. cinnabarinus at 0.625 mg/L. In the field trials, compounds (Vc), (Ve) and (Vf) were evaluated against Panonychus ulmi and Panonychus citri at three different concentrations. The results showed that compounds (Ve) and (Vf) have the potential to develop into new proacaricide with further test and toxicity evaluation.