Synthesis, cytotoxicity, and molecular docking of methylated (–)-epigallocatechin-3-gallate-4β-triazolopodophyllotoxin derivatives as novel antitumor agents:

Cheng-Ting Zi,Ze-Hao Wang,Jing Shi,Bo-Ya Shi,Ning Zhang,Yi-Long Wu,Yin-Rong Xie,Lu Zhou,Chun Xiao,Xuan-Jun Wang,Jun Sheng

Synthesis, cytotoxicity, and molecular docking of methylated (–)-epigallocatechin-3-gallate-4β-triazolopodophyllotoxin derivatives as novel antitumor agents:

2021

Cheng-Ting Zi
Ze-Hao Wang
Jing Shi
Bo-Ya Shi
Ning Zhang
Yi-Long Wu
Yin-Rong Xie
Lu Zhou
Chun Xiao
Xuan-Jun Wang
Jun Sheng

A series of novel methylated (–)-epigallocatechin-3-gallate-4β-triazolopodophyllotoxin derivatives is synthesized by utilizing the click reaction. Evaluation of their cytotoxicity against a panel o...

Keywords:

Combinatorial chemistry
Chemistry
Click chemistry
antitumor activity
Gallate
Cytotoxicity
Podophyllotoxin

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