Control of a robotic prosthesis simulation by a closed-loop intracortical brain-machine interface.

Closed-loop brain-machine interfaces may help restore the autonomy of amputees and tetraplegic patients. However, additional efforts are needed towards their real-world use with prostheses. Here we have interfaced a highly versatile closed-loop mouse BMI with an online model of a real-world prosthetic arm. We describe this setup and illustrate how it allows to explore the efficiency of different input and output coding strategies given a realistic modelling of the interactions between a commercial bidirectional prosthesis and its environment.