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l'Oreal has, based on these principles, developed unique test methods to screen and test potential effects of chemicals. We initially focused on approaches for skin irritation, since this is an important endpoint for chemicals used in cosmetics. A peer review on various aspects of alternative techniques was per - formed at all stages of the research, and development had the focus that in vitro methods improve chemical selection (screen - ing) as well as quality of testing. Following the development of the screening test, we implemented some protocols (i.e. epiSkin