Auto-tuning oscillator for the generation of nonthermal plasma as a therapeutic treatment for melanoma

Nonthermal plasma has shown promising results as a treatment method for melanoma cancer cells. However, the implementation of nonthermal plasma for melanoma cancer cell therapy is hindered by the need for precise setup and constant manual reconfiguration. This work presents a new automated approach for the generation of nonthermal plasma that can maintain a stable plume with no user intervention, while reducing form factor and cost. In contrast to expensive impedance matching plasma generators that operate at higher frequencies, this work employs a closed loop feedback algorithm, which utilizes AC amplitude and DC current measurement to adjust the frequency to produce a stable plume.