COMPARATIVE EVALUATION OF THE EFFECT OF PSYCHOACTIVE MEDICINES ON HIPPOCAMPAL THETA AND GAMMA RHYTHMS

The work was performed on cats with electrodes stereotactically implanted in various parts of the brain. The effect of melatonin, atomoxetine and chlorpromazine on cerebral cortex structures with different phylogenetic organization and on the hippocampus in particular was studied. A normalization of FFT-transformed brain electrograms was conducted. The electrograms were recorded under the influence of the agents under study, which exhibit an activating and depressing effect recorded by the main pharmacokinetic points. Although the psychoactive agents demonstrate different neurochemical and clinical-pharmacological properties, their effects are most clearly seen on brain electrograms by the activity of hippocampal θ and γ rhythms that reflect mesolimbic mechanisms. These mechanisms are characterized by uniqueness of action during the entire period of influence, which coincides with the pharmacodynamic and pharmacokinetic data. These manifestations reflect the effect of the studied psychoactive agents on the fundamental mechanisms of the brain consisting, e.g., in the transformation of intracenter relations and the formation of cognitive functions.