CRISPR/Cas9 targeting events cause complex deletions and insertions at 17 sites in the mouse genome
2017
CRISPR/Cas9 gene editing has been used to generate mutations in several mouse genes. Here, the authors show that targeting events using single guide RNAs cause large deletions at 17 sites in the mouse genome, suggesting that careful genotyping is needed and sequential targeting may avoid such deletions.
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