A TNF- and c-Cbl-dependent FLIP S -degradation pathway and its function in Mycobacterium tuberculosis –induced macrophage apoptosis

Manikuntala Kundu,Sushil Kumar Pathak,Kuldeep Kumawat,Sanchita Basu,Gargi Chatterjee,Shresh Pathak,Takuya Noguchi,Kohsuke Takeda,Hidenori Ichijo,Christine B.F. Thien,Wallace Y. Langdon,Joyoti Basu

A TNF- and c-Cbl-dependent FLIP S -degradation pathway and its function in Mycobacterium tuberculosis –induced macrophage apoptosis

2009

Manikuntala Kundu
Sushil Kumar Pathak
Kuldeep Kumawat
Sanchita Basu
Gargi Chatterjee
Shresh Pathak
Takuya Noguchi
Kohsuke Takeda
Hidenori Ichijo
Christine B.F. Thien
Wallace Y. Langdon
Joyoti Basu

Apoptosis of Mycobacterium tuberculosis (Mtb)-infected macrophages restricts the spread of infection. Basu and colleagues delineate the signaling pathway needed for death of Mtb-infected cells.

Keywords:

Cell biology
Ubiquitin ligase
Immunology
Mycobacterium tuberculosis
Flip
Tumor necrosis factor alpha
Signal transduction
Apoptosis
Macrophage apoptosis
Biology
Programmed cell death
degradation pathway

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