Aptamers for ß-NGF and their use in the treatment of diseases and disorders mediated by ß-NGF

An aptamer consisting of the sequence BAZGRGGRSN (0-1) ZWGGGGN (0-1) ZZWADCCGZZRZG (SEQ ID NO: 154), wherein B is selected from a C, a G or Z; R is independently selected from an A or G selected; S is selected from a C or G; W is independently selected from one or Z T selected; D is selected from an A, one G or Z; N are independently any nucleotide or modified natural origin selected; and Z is a modified pyrimidine; wherein the aptamer binds to NGF-s with a Kd of 30 nM or less.