A Novel Synthesis of Sex Pheromone from the Longicorn Beetle(Psacothea hilaris)
2021
An asymmetric synthesis of (8Z,21R)-21-methylpentatriacont-8-ene, the sex pheromone
of the yellow-spotted longicorn beetle Psacothea
hilaris, has been achieved using Evan’s induction as the key
step. Based on the asymmetric methylation product of chiral (R)-4-benzyl-1,3-oxazolidin-2-one, the carbon chain
of the target molecule was assembled through a
C5+C12+C11+C8
sequence. (2R)-4-(Benzyloxy)-2-methylbutan-1-ol, which can be obtained from
γ-lactone following Evan’s protocol, was connected to a
C12 alkyl group. The chiral methyl group remained the
key moiety (97% ee). After another Wittig
reaction and catalytic hydrogenation step, the designed key intermediate
(13R)-13-methylheptacosan-1-ol was
obtained. Finally, after oxidation and Wittig reaction, the synthesis of the
target molecule was completed in 10 linear steps with an ultra-high overall
yield of 36.2%.
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