Mir-17-92 regulates bone marrow homing of plasma cells and production of immunoglobulin G2c.

After activation and selection, plasma cells home to the bone marrow where they persist and continue to make antibodies. Here the authors show that the mir-17–92 cluster coordinates the process by regulating the homing receptor S1PR1 and the transcription factor IKAROS that controls IgG2c production.