Naturally occurring N6-substituted adenosines (cytokinin ribosides) are in vitro inhibitors of platelet aggregation : An in silico evaluation of their interaction with the P2Y12 receptor

Abstract A few naturally occurring N 6 -substituted adenosine derivatives (cytokinin ribosides) were investigated as inhibitors of platelet aggregation induced in vitro by collagen and their activity range was demonstrated (IC 50 : 6.77–141 μM). A docking study suggests that anti-aggregation activity of these compounds could involve an interaction with the P2Y 12 receptor binding site.