Acid compounds (aryl, heteroaryl, arylmethyl or heteroarylmethyl) hydroxamic substituted.

This invention is directed to compounds of formula (I), in which the variables are as described herein. The compounds within the scope of the present invention possess useful properties, more particularly pharmaceutical PROPERTIES. Especially useful for inhibiting or production of TNF PHYSIOLOGICAL EFFECTS IN THE TREATMENT OF A patient suffering from a disease state associated with FISIOLOGICMENTE HARMFUL EXCESS OF TUMOR NECROSIS FACTOR (TNF). The compounds within the scope of the present invention also inhibit CYCLIC AMP phosphodiesterase, and are useful for treating a disease condition associated with impaired PATHOLOGICAL ARE modulated by inhibition of CYCLIC AMP phosphodiesterase INCLUDING SUCH STATES OF DISEASE INFLAMMATORY DISEASES AND AUTOIMMUNE , INCLUDING THE CYCLIC AMP phosphodiesterase type IV. COMPOUNDS WITHIN THE SCOPE OF THIS invention may also inhibit MMP, and are useful for treating a disease condition associated with impaired PATHOLOGICAL ARE MODULADOS by inhibiting MMP, INCLUDING SUCH STATES OF ILLNESS Disintegration TISSUE AND ASSOCIATED STATES physiologically with excess TNF HARMFUL. THEREFORE, THIS IS ALSO THE INVENTION ADDRESSED TO USE THE PHARMACIST compounds, pharmaceutical compositions containing the compounds, intermediates LEADING TO THE FORMATION OF THESE AND PROCEDURES FOR THE PREPARATION OF THE COMPOUNDS AND INTERMEDIATE.