Pitiamides A and B, Multifunctional Fatty Acid Amides from Marine Cyanobacteria
2016
Two geometric isomers related to pitiamide A, termed 1 E -pitiamide B ( 1 ) and 1 Z -pitiamide B ( 2 ), were isolated from a marine cyanobacterium collected from the shallow reef flat at Piti Bomb Holes, Guam, Mariana Islands. The structures of these analogues were elucidated using 1D and 2D NMR analysis. Pitiamide A, which has been previously described, but has not been investigated in bioassays, was co-isolated. Pitiamides A and B were subjected to a biological evaluation and they both showed antiproliferative effects on HCT116 cells with IC 50 values of 1–5 µM. Pitiamide A was investigated individually and caused plasma membrane hyperpolarization and an increase of intracellular calcium in HCT116 cells.
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