Serendipitous synthesis of novel dehydro- and dechloro-pseudomycin B (PSB) derivatives.

Yan-Zhi Zhang,Robert Boyer,Xicheng Sun,Jonathan W. Paschal,Shu-Hui Chen

Serendipitous synthesis of novel dehydro- and dechloro-pseudomycin B (PSB) derivatives.

2000

Yan-Zhi Zhang
Robert Boyer
Xicheng Sun
Jonathan W. Paschal
Shu-Hui Chen

The syntheses and preliminary investigation of antifungal activities of two dehydro PSB derivatives 8 and 10 as well as one 3-imido-9-dechloro PSB analogue 13 are described.

Keywords:

Pseudomycin B
Antifungal
Cyclic peptide
Lactone
Stereochemistry
Biochemistry
Chemistry

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