Effect of the Wavelength and Intensity of Excitation Light on the Efficiency of Photogeneration of Singlet Oxygen by Photodithazine in the Presence of Pluronic F127 in Model Processes of Photo-Oxidation

A study is performed of the effect amphiphilic polymer Pluronic F127 has on the activity and photostability of photodithazine (PZ) in the photogeneration of singlet oxygen (1О2) in a model reaction of photo-oxidation of tryptophan in water upon excitation with light at λ = 400 and 660 nm at different light power densities. The highest photocatalytic activity and photostability of photodithazine in 1O2 generation are observed upon excitation with light at a wavelength of 400 nm, a medium radiation power density, and in the presence of Pluronic F127 in the reaction medium. The model reactions can be used to select the photosensitizers (PS) of the system (the presence of amphiphilic polymer and other systems added along with photosensitizers) and the modes of the low-energy photodynamic effects on substrates characteristic of each photosensitizer that are most favorable for therapy (i.e., that contribute to the initiation of regenerative and immune processes).