Optimization of Extraction Technology for Sishen Colon Targeting Tablets by Orthogonal Design Test

Objective:To optimize extraction technology for Sishen colon targeting tablets by orthogonal test design.Method:L9(34) orthogonal test was used for optimizing content determination extraction technology for Sishen colon targeting tablets with the concentration of ethanol,the amount of solvent,extraction times and extraction time as investigation factors,extraction rate and extract yield of psoralen,isopsoralen,evodiamine,rutaecarpine was taken as indexes.Result:Optimum extraction technology was as follows:reflux extracted 3 times with 8 times the amount of 60%ethanol for 1.5 h each time.Conclusion:Optimized extraction technology was rational with high extraction efficiency,it was suitable for industrial production.